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Fox’s gripping medical drama Doc returns for its second season with 22 new episodes filled with medical mysteries, emotional dilemmas, and a tense hostage crisis that sparks a breakthrough for Dr. Amy Larsen (Molly Parker). Still grappling with the nearly decade-long memory loss caused by a car crash, Amy begins an urgent quest to recover her past while balancing high-stakes cases at Westside Hospital. Her love life remains complicated as she navigates feelings for her married ex-husband Michael (Omar Metwally) and colleague Jake (Jon-Michael Ecker), whose family life comes into focus this season. Meanwhile, her neuropsychiatrist best friend Gina (Amirah Vann) supports Amy through risky treatments like transcranial magnetic stimulation and sensory-deprivation therapy, even as their friendship faces new strains.
The hospital welcomes a new chief of internal medicine, Dr. Joan Ridley (Felicity Huffman), Amy’s tough former mentor whose hidden health struggles contrast with her fierce ambition to make Westside the best hospital in the state. Joan clashes with Amy’s newfound empathetic approach, pushing her to return to her old, detached style. Adding to the intrigue is ambitious intern Hannah (Emma Pfitzer Price), whose troubled past and mysterious connection to Amy’s flashbacks introduce dangerous new twists. With life-or-death cases, evolving relationships, and secrets waiting to be uncovered, Doc continues to blend medical drama with a detective-like unraveling of Amy’s lost years.